Human papillomavirus oncogenes expression

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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and Human papillomavirus oncogenes expression oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle.

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Human papillomavirus oncogenes expression, Implicarea genomului papiloma virusului uman hpv în oncogeneza cancerului cervical The role of the p16 biomarker in cervical precancer Material and method: Sixty patients human papillomavirus oncogenes expression included in our study. All of the patient underwent colposcopy-guided biopsy to asses the grade of CIN. For the immunohistochemistry exam we used p16INK4A and Ki antibody and their expression was semiquantitatively classified in 4 classes: 0, 1, 2 and 3. Results: 7 human papillomavirus oncogenes expression our cases were benign Cancer burden in the year The global picture.

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All of the patient underwent colposcopy-guided biopsy to asses the grade of CIN. For the immunohistochemistry exam we used p16INK4A and Ki antibody and their expression was semiquantitatively classified in 4 classes: 0, 1, 2 and 3. Results: 7 of human papillomavirus oncogenes expression cases were benign 2.

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